•Your PFC weakens, making it harder to manage stress.
•Your amygdala overreacts, making everything feel overwhelming.
•Your HPA axis burns out, leaving you physically and mentally exhausted.
•Your dopamine and serotonin drop, making things feel meaningless.
•Your brain structure changes, making it harder to recover quickly.
This is why burnout feels like mental fog, emotional detachment, exhaustion, and apathy all at once. It's not just "being tired"—it's your brain physically struggling to function properly.
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Burnout is a prolonged stress response that overloads your brain’s systems, mainly involving three key areas: the prefrontal cortex, the amygdala, and the HPA axis (hypothalamic-pituitary-adrenal axis).
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